Comments for Thirst for Science http://wrightfisher.wordpress.com drinking the koolaid Sun, 06 Jul 2008 17:09:09 +0000 http://wordpress.org/?v=MU Comment on Histone Replacement / Turnover by On nucleosome positioning « Thirst for Science http://wrightfisher.wordpress.com/2007/11/04/histone-replacement-turnover/#comment-88 On nucleosome positioning « Thirst for Science Tue, 13 May 2008 13:58:51 +0000 http://wrightfisher.wordpress.com/2007/11/04/histone-replacement-turnover/#comment-88 [...] nucleosomes has to do with histone dynamics. I’ve written before about some elegant work on Histone Turnover, but recently Shivaswamy et. al. took a different approach to the problem. They compared the [...] [...] nucleosomes has to do with histone dynamics. I’ve written before about some elegant work on Histone Turnover, but recently Shivaswamy et. al. took a different approach to the problem. They compared the [...]

]]> Comment on Biophysics of Transcriptional Regulation by ellen http://wrightfisher.wordpress.com/2008/04/24/38/#comment-87 ellen Mon, 05 May 2008 19:15:29 +0000 http://wrightfisher.wordpress.com/?p=38#comment-87 I had a related question about cell differentiation in eukariotes.how does proximity in DNA location relate to cell differentiation? Are genes which turn on in bundles to make a cell of a certain type, typically located close to one another, so that they could be easily unpacked during development? one could imagine that the hierarchical structure of differentiation can be reflected somehow in the position on the genome. Any evidence for that? I had a related question about cell differentiation in eukariotes.how does proximity in DNA location relate to cell differentiation? Are genes which turn on in bundles to make a cell of a certain type, typically located close to one another, so that they could be easily unpacked during development? one could imagine that the hierarchical structure of differentiation can be reflected somehow in the position on the genome. Any evidence for that?

]]> Comment on Biophysics of Transcriptional Regulation by son1 http://wrightfisher.wordpress.com/2008/04/24/38/#comment-78 son1 Thu, 24 Apr 2008 20:34:45 +0000 http://wrightfisher.wordpress.com/?p=38#comment-78 How much do you think that nuclear 3d structure could play a similar role, in eukaryotes? Imagine a situation in which the chromosomes are packed into the nucleus in such a way that certain parts of particular chromosomes are near certain convenient pores in the nucleus -- particular factors might be shuttled through particular pores, even, and would be much more likely to find the binding sites that are physically close to those points-of-entry. You'd be in this crazy situation where regulation could occur simply be re-arranging the chromosomes within the nucleus itself. (!) [On the other hand, maybe differential binding of transcription factors to "equivalent" sequence elements could give you rough distance measurements, sort of genomic mile-markers, of the location of each binding event from the nuclear port of entry for that factor...] How much do you think that nuclear 3d structure could play a similar role, in eukaryotes? Imagine a situation in which the chromosomes are packed into the nucleus in such a way that certain parts of particular chromosomes are near certain convenient pores in the nucleus — particular factors might be shuttled through particular pores, even, and would be much more likely to find the binding sites that are physically close to those points-of-entry.

You’d be in this crazy situation where regulation could occur simply be re-arranging the chromosomes within the nucleus itself. (!)

[On the other hand, maybe differential binding of transcription factors to "equivalent" sequence elements could give you rough distance measurements, sort of genomic mile-markers, of the location of each binding event from the nuclear port of entry for that factor...]

]]> Comment on Predicting Drosophila Segmentation by Ceceliadc http://wrightfisher.wordpress.com/2008/02/28/predicting-drosophila-segmentation/#comment-62 Ceceliadc Wed, 26 Mar 2008 21:34:08 +0000 http://wrightfisher.wordpress.com/?p=33#comment-62 omg.. good work, bro omg.. good work, bro

]]> Comment on A quick break for Comics by son1 http://wrightfisher.wordpress.com/2008/02/26/a-quick-break-for-comics/#comment-40 son1 Tue, 26 Feb 2008 15:52:01 +0000 http://wrightfisher.wordpress.com/?p=30#comment-40 Obviously, we're both using our time well this morning. The difference is, <i>you</i> don't have to give a group meeting tomorrow :-). Obviously, we’re both using our time well this morning. The difference is, you don’t have to give a group meeting tomorrow :-).

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