Location, location, location

September 13, 2010

A reoccurring thought recently has been that old realtor’s mantra “Location, Location, Location”. A tremendous amount of regulation is likely to be simply the process of controlled localization. This is an old mantra in biochemistry where reaction rates can be changed by simply changing the concentrations of either reactants, products or enzyme to drive the reaction in a suitable direction. The cell takes advantage of this in localizing some reactions to particular organelles. But there is reason to believe that localization effects drive much more than just the metabolism of the cell.

For example, transcription factors can be localized to the nucleus or cytoplasm by phosphorlyation state (Pho4 for example). Messages can be localized within the cell by ribosomal binding proteins and information encoded in their 3′ UTRs.

How do we best study localization?

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: